Hydroquinone

CAS: 123-31-9 | Synonyms: 1,4-Benzenediol, 1,4-Dihydroxybenzene, Quinol +2

Safer alternative: Arbutin

Toxicity Score

8 /10
Avoid

Primary Concern

Skin irritation

Found In

Skin Lightening Creams, Dark Spot Treatments, Fade Creams

Persona Risk

High Risk for Skin & Allergy

Put Simply

Hydroquinone is an ingredient used in creams and treatments to lighten dark spots or pigmentation on the skin. While it can be effective, it might cause skin irritation or even lead to a condition where the skin turns a blue-black color over time. There's also some concern about it being linked to cancer risk, which is why it's regulated or banned in some places.

Clinical Summary

Hydroquinone is commonly used for skin lightening in cosmetic formulations. It is effective in treating hyperpigmentation but has been associated with adverse effects such as skin irritation and ochronosis, a condition characterized by blue-black pigmentation. There is also concern about its potential carcinogenic effects, leading to its regulation or ban in several countries.

Identified Health Risks

Skin irritation
Increased risk of ochronosis
Potential carcinogenicity

What This Score Means

Avoid. This ingredient scores 8/10 on our toxicity scale. Strong clinical evidence links it to serious health concerns. We recommend swapping any product containing this ingredient.

Regulatory Status

Cross-referenced safety assessments from regulatory bodies

Organization
Rating
Concern
EWG
High Hazard
Organ system toxicity, Irritation
ECHA
Carcinogenic, Mutagenic, or Reproductive Toxicant
Potential cancer risk
FDA
Banned in OTC products
Potential carcinogenic effects

Also Listed On Labels As

1,4-Benzenediol 1,4-Dihydroxybenzene Quinol p-Dihydroxybenzene Tequinol

Risk by Health Profile

Skin & Allergy High Risk

Can cause skin irritation and contact dermatitis, particularly in individuals with sensitive skin.

Chronic & Autoimmune Medium Risk

Prolonged use may lead to ochronosis, a chronic condition with irreversible skin discoloration.

Hormone & Endocrine Low Risk

Limited evidence of endocrine disruption but flagged by some studies.

Frequently Asked Questions

Sources & Citations

  1. [1]
    PubMed Central (PMID: 2088328)
  2. [2]
  3. [3]

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